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Viruslike particles in malaria parasites

J A Terzakis, J P Vanderberg, M M Weiss

    The Journal of Parasitology
    |June 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

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    Ultrastructural analysis reveals viruslike particles in malaria parasites during sporogony. Geometric aggregations in early stages suggest nascent virus forms, distinct from dispersed later stages.

    Area of Science:

    • Parasitology
    • Virology
    • Cell Biology

    Background:

    • Malaria parasites exhibit complex life cycles involving various developmental stages.
    • The presence and nature of viruslike particles (VLPs) in parasites are not fully understood.
    • Sporogony is a critical phase in the malaria parasite's life cycle within the mosquito vector.

    Purpose of the Study:

    • To detail the ultrastructural characteristics of VLPs during malaria parasite sporogony.
    • To compare VLP morphology and aggregation patterns across different parasite species and developmental stages.
    • To investigate the potential implications of observed VLP structures, particularly geometric aggregations.

    Main Methods:

    • Transmission electron microscopy (TEM) was used to examine VLPs in Plasmodium berghei, Plasmodium gallinaceum, and Plasmodium cynomolgi bastianelli.

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  • Negative staining techniques were applied to fractionated mosquito midguts infected with P. berghei.
  • Morphometric analysis focused on particle size (42-52 nm), density, and aggregation patterns.

    • Main Results:

    • VLPs were observed in ookinetes and oocysts of malaria parasites at various sporogonic times.
    • Early oocysts and ookinetes showed geometric aggregations of smaller diameter VLPs lacking envelopes.
    • Later oocyst stages displayed dispersed VLPs with similar size and shape to those in early aggregates.
    • VLPs from infected mosquito midguts shared characteristics with those observed in parasite stages.

    Conclusions:

    • Geometric VLP aggregations in early sporogonic stages may represent an incomplete or nascent virus particle form.
    • VLP morphology remains consistent in size and shape, whether aggregated or dispersed, throughout sporogony.
    • These findings contribute to understanding virus-parasite interactions in malaria transmission.