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The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein
A Madani1, J Soulier, M Schmid
1Laboratoire d'Hématologie Moléculaire, Hôpital Saint Louis, Paris, France.
Oncogene
|June 1, 1995
Abstract:
An unusually small (8 kD) protein (p8MTCP-1) is coded by the putative oncogene MTCP-1 (also called c6.1B), involved in the translocation t(X;14)(q28;q11) associated with some mature T-cell proliferations. Here, we show by subcellular fractionation and by confocal microscopy that this protein is located in the mitochondria. This localization orientates toward a role of p8MTCP-1 in the mitochondrial metabolism which may be relevant for the oncogenic process.