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Related Experiment Videos

DMSO in otology

G R Freeman

    The Laryngoscope
    |July 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Dimethyl sulfoxide (DMSO) was investigated for therapeutic properties. Clinical trials revealed DMSO lacks antibacterial, anesthetic, or anti-inflammatory effects in the ear canal, despite attributed healing powers.

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    Area of Science:

    • Pharmacology
    • Dermatology
    • Otolaryngology

    Background:

    • Dimethyl sulfoxide (DMSO) is an industrial solvent with attributed therapeutic properties.
    • DMSO was experimentally used in veterinary and clinical medicine for pain relief, swelling reduction, and anesthetic, antibacterial, and anti-inflammatory effects.
    • Ninety percent DMSO was applied topically, alone and with other agents, to evaluate its clinical efficacy.

    Purpose of the Study:

    • To assess the antibacterial, anesthetic, and anti-inflammatory properties of dimethyl sulfoxide (DMSO).
    • To determine if DMSO enhances the penetration of other agents through the dermal barrier.
    • To evaluate DMSO's efficacy in treating otological infections.

    Main Methods:

    • Laboratory testing and clinical trials, including double-blind studies.

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  • Application of 90% DMSO alone and in conjunction with alkaloids and antibiotics.
  • Testing DMSO's effects when applied within the external auditory canal.

    • Main Results:

    • DMSO was found not to be ototoxic.
    • Clinical studies demonstrated DMSO had no antibacterial, anesthetic, or anti-inflammatory properties in the external auditory canal.
    • No evidence suggested 90% DMSO potentiated or synergistically enhanced the penetration of combined preparations through the dermal barrier.

    Conclusions:

    • Dimethyl sulfoxide (DMSO) does not possess the attributed antibacterial, anesthetic, or anti-inflammatory properties when applied to the external auditory canal.
    • DMSO did not enhance the dermal penetration of other therapeutic agents.
    • The widespread therapeutic claims for DMSO in otological applications are not supported by clinical evidence.