[Chronic atrophic gastritis as a precursor to gastric carcinoma]

According to clinical and histological researches, a conclusion can be accepted that the chronic atrophic gastritis is a very serious precancerous condition of stomach. Biological key and connection between these two entities seemed to be intestinal metaplasia, but it has been suggested lately, that the dysplasia of gastric mucose was responsible for malignant proliferation in stomach mucose. The aim of this study was to determine the precancerous potential of the chronic atrophic gastritis, measuring the frequency of dysplasia of gastric mucose, type II and III, which are considered as precancerous lesions. The results (according to t-test) in the tested group (61 patient with histologically proved chronic atrophic gastritis) comparing to the control group (64 healthy persons), showed statistically highly significant difference in appearance of dysplasia of gastric mucose type II and III. It confirms high precancerous potential of the chronic atrophic gastritis and the need for frequent endoscopic and histologic examinations of these patients.