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[Comparison between 2 steroid dosage forms in psoriasis and eczema]
Zeitschrift Fur Hautkrankheiten
|January 1, 1975
Summary
A new topical steroid, desoximetasone, demonstrated superior efficacy compared to betamethasone 17-valerate for treating atopic dermatitis and psoriasis. The study found desoximetasone significantly improved psoriasis symptoms.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Atopic dermatitis and psoriasis are common inflammatory skin conditions.
- Topical corticosteroids are a mainstay treatment for these conditions.
Purpose of the Study:
- To evaluate the clinical efficacy of a novel topical steroid, desoximetasone (A 41 304).
- To compare desoximetasone against a potent comparator, betamethasone 17-valerate.
Main Methods:
- Randomized, double-blind, right-left comparative trial.
- Inclusion of 22 patients with atopic dermatitis and 24 patients with psoriasis.
Main Results:
- Desoximetasone showed a better therapeutic effect in both atopic dermatitis and psoriasis.
- The observed difference in efficacy was statistically significant (p < 0.005) for psoriasis.
Conclusions:
- Desoximetasone is a highly effective topical steroid for managing atopic dermatitis and psoriasis.
- Its superior efficacy, particularly in psoriasis, warrants further clinical consideration.