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Related Experiment Videos

Ipratropium bromide and intraoperative bronchospasm

W M Ho1, K C Wong

  • 1Department of Anesthesiology, Taichung Veterans General Hospital, Taiwan, R.O.C.

Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed
|April 1, 1995
PubMed
Summary

Inhaled ipratropium bromide (IB) effectively managed intraoperative bronchospasm in asthmatic patients post-intubation. This bronchodilator reduced airway pressure and resistance without affecting heart rate.

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Area of Science:

  • Anesthesiology
  • Pharmacology
  • Respiratory Medicine

Background:

  • Ipratropium bromide (IB) is an inhaled anticholinergic bronchodilator.
  • It may be effective for managing intraoperative bronchospasm.
  • This study evaluated inhaled IB for bronchospasm induced by endotracheal intubation.

Purpose of the Study:

  • To assess the efficacy of inhaled ipratropium bromide in managing intraoperative bronchospasm.
  • To investigate the effects of IB on respiratory parameters during endotracheal intubation in asthmatic patients.

Main Methods:

  • Nine asymptomatic asthmatic patients undergoing endotracheal intubation were studied.
  • 120 micrograms of IB was aerosolized via the endotracheal tube.
  • Peak inspiratory pressure (PIP), airway resistance (Raw), and pulmonary resistance (Rpul) were measured before and after IB administration.

Main Results:

  • IB administration relieved wheezing within 11 minutes.
  • Significant decreases in PIP, Raw, and Rpul were observed post-IB.
  • Peak therapeutic effects were noted at 120 minutes, with no significant changes in heart rate.

Conclusions:

  • Inhaled ipratropium bromide (120 micrograms) effectively abates intraoperative bronchospasm.
  • It is beneficial for asthmatic patients with airway hyperreactivity post-intubation.
  • IB may play a role in managing intraoperative bronchospasm.

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