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Luteal phase defects and ectopic pregnancy

A J Guillaume1, F Benjamin, B Sicuranza

  • 1Catholic Medical Center of Brooklyn and Queens, New York.

Fertility and Sterility
|January 1, 1995
PubMed
Summary
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Luteal phase defect (LPD) significantly increases the risk of ectopic pregnancy (EP) and miscarriage. Early ultrasound is recommended for pregnant patients with LPD to rule out EP.

Area of Science:

  • Reproductive Endocrinology
  • Infertility Research
  • Obstetrics and Gynecology

Background:

  • Luteal phase defect (LPD) is a potential cause of infertility.
  • Ectopic pregnancy (EP) is a significant obstetric complication.

Purpose of the Study:

  • To investigate the association between LPD and EP.
  • To determine if LPD is an etiological factor in EP.

Main Methods:

  • Prospective follow-up of 1,077 infertility patients over six years.
  • Comparison of EP and miscarriage rates in patients with LPD versus anovulation.

Main Results:

  • The EP rate was significantly higher in patients with LPD (6/51) compared to controls (6/210).
  • Spontaneous abortion rates were also significantly higher in LPD cases (19/51) versus controls (12/210).

Related Experiment Videos

  • Untreated LPD patients had higher EP and miscarriage rates than treated patients.

    • Conclusions:

    • LPD is associated with a significantly increased incidence of tubal EP.
    • Early ultrasound is recommended for pregnant patients with LPD to detect EP.
    • LPD cases have a high incidence of spontaneous abortion.