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Dystonic-like reaction following cisapride therapy
K K Bucci1, D E Haverstick, S A Abercrombie
1Medical University of South Carolina, Greenwood.
The Journal of Family Practice
|January 1, 1995
Summary
Gastroesophageal reflux disease treatment with cisapride can cause dystonic-like reactions. Discontinuation of cisapride led to complete recovery in a patient experiencing these adverse effects.
Area of Science:
- Neurology
- Pharmacology
Background:
- Gastroesophageal reflux disease (GERD) is a common condition.
- Cisapride is a medication used to treat GERD.
- Adverse drug reactions can occur with cisapride therapy.
Observation:
- A 43-year-old woman with GERD developed unusual movements.
- Symptoms included rhythmic head movements, unresponsiveness, increased neck muscle tone, tongue protrusion, and gait disturbance.
- These symptoms appeared 3 days after initiating oral cisapride.
Findings:
- The patient exhibited a dystonic-like reaction.
- The reaction was temporally associated with the initiation of cisapride treatment.
- Complete resolution of symptoms occurred after cisapride discontinuation.
Implications:
- Cisapride may induce dystonic-like reactions.
- Awareness of potential neurological side effects is crucial for clinicians prescribing cisapride.
- Prompt recognition and drug withdrawal can lead to full patient recovery.