Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solid tumours--chemoprevention with retinoids

T Man1

  • 1Roche International Clinical Research Centre, Lingolsheim, France.

Leukemia
|January 1, 1994
PubMed
Summary

Retinoids show promise in preventing new cancers, particularly in head and neck and breast cancer patients. Further research is needed to overcome challenges in clinical trial design and patient selection for effective retinoid chemoprevention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk factors for new-onset diabetes mellitus following acute pancreatitis: a prospective study.

European review for medical and pharmacological sciences·2022
Same author

Leptin involvement in the survival of pancreatic adenocarcinoma patients with obesity and diabetes.

European review for medical and pharmacological sciences·2022
Same author

The mechanics of mitotic chromosomes.

Quarterly reviews of biophysics·2021
Same author

Solid tumours--chemoprevention with retinoids.

Leukemia·1994
Same author

EVA treatment for recurrent or unresponsive Hodgkin's disease.

Cancer chemotherapy and pharmacology·1986
Same author

[Incidence of B. cereus in raw milk and pasteurized milk].

Microbiologia, parazitologia, epidemiologia·1966

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Solid tumor treatment is shifting towards early-stage intervention.
  • Retinoids are a promising drug class for cancer chemoprevention.
  • Different retinoids exhibit varying antitumor activities and synergistic potential with cytokines.

Framework:

  • Understanding retinoid receptor roles can optimize drug design for better therapeutic indices.
  • 13-cis retinoic acid shows efficacy in preventing second primary head and neck cancers.
  • Fenretimide is under investigation for preventing second primary breast cancers.

Implementation:

  • Clinical development of retinoids faces challenges in study design and preclinical model relevance.
  • Optimal patient selection, dosing, scheduling, and treatment duration require further definition.
  • Biological surrogate markers can accelerate clinical trial development for chemopreventive agents.

Implications:

  • Ongoing studies, especially in tobacco-related diseases, will clarify retinoids' role in cancer prevention.
  • Large, well-organized clinical studies are crucial for advancing retinoid chemoprevention.
  • Retinoids offer a potential strategy for reducing cancer recurrence and new primary tumor development.

Related Experiment Videos