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Solid tumours--chemoprevention with retinoids
1Roche International Clinical Research Centre, Lingolsheim, France.
Leukemia
|October 1, 1994
Summary
Retinoids show promise in preventing early-stage cancers and second primary tumors. Further research is needed to overcome challenges in clinical development for these chemoprevention agents.
Area of Science:
- Oncology
- Chemoprevention
Background:
- Cancer treatment is shifting towards early-stage disease.
- Retinoids are a promising class of drugs for cancer chemoprevention.
- Different retinoids exhibit varying antitumoral activities and can synergize with cytokines.
Purpose of the Study:
- To explore the potential of retinoids in cancer chemoprevention.
- To investigate the role of retinoid receptors in designing more effective compounds.
- To address challenges in the clinical development of retinoid-based chemoprevention strategies.
Main Methods:
- Review of preclinical data and clinical experience with retinoids.
- Evaluation of existing and ongoing clinical studies for retinoid efficacy.
- Discussion of challenges in study design, patient selection, and trial endpoints.
Main Results:
- 13-cis retinoic acid shows activity in preventing head and neck second primary tumors.
- Fenretidinide is under investigation for breast cancer second primary tumor prevention.
- Understanding retinoid receptor function could lead to improved therapeutic indices.
Conclusions:
- Retinoids hold potential for cancer chemoprevention, particularly for early-stage disease and second primary tumors.
- Significant challenges remain in clinical development, including study design and patient selection.
- Further clinical studies, especially in tobacco-related cancers, are crucial to define the role of retinoids.