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[Hemophilus influenzae meningitis despite vaccination]
U Jurgenson1, A Asia, R Arav-Boger
1Souraski--Tel Aviv Medical Center, Dana Children's Hospital.
Harefuah
|October 1, 1994
Summary
Even fully vaccinated children can develop Hemophilus influenzae type B meningitis. This case highlights the need to consider this serious infection despite complete immunization schedules.
Area of Science:
- Pediatrics
- Infectious Diseases
- Immunology
Background:
- Routine childhood vaccination includes protection against Hemophilus influenzae type B (Hib).
- Hib conjugate vaccines (HbOC) are highly effective in preventing Hib infections.
Observation:
- An 18-month-old male presented with meningitis.
- The child had received 4 doses of HbOC vaccine.
- The patient's immunological status and Hib antibody titers were within normal ranges for immunized individuals.
Findings:
- Meningitis was confirmed to be caused by Hemophilus influenzae type B.
- This occurred despite the child being fully vaccinated according to schedule.
Implications:
- Hib meningitis can occur in fully vaccinated children.
- Clinical suspicion for Hib meningitis should be maintained even in immunized populations.
- Further research may be needed to understand vaccine breakthrough cases.