Related Experiment Videos
Increased frequency of micronuclei in lymphocytes of Swedish chimney sweeps
A Holmén1, A Karlsson, I Bratt
1Department of Occupational Medicine, Central Hospital, Halmstad, Sweden.
International Archives of Occupational and Environmental Health
|January 1, 1994
Abstract:
Forty-five Swedish chimney sweeps and 49 controls were investigated with micronuclei stimulated by phytohemagglutinin and pokeweed mitogen and by analysis of lymphocyte subgroups and neutrophilic leukocytes. There was a statistically significant effect among sweeps with respect to both micronuclei variables and neutrophilic leukocytes. The effect on lymphocyte micronuclei was most prominent in pokeweed mitogen-stimulated cells, which may imply that the T4 lymphocytes were preferentially damaged by the occupational exposure.