[New viewpoints on the development, maturation, and aging of cataneous connective tissue]

The clinical theoretical findings on skin connective tissue during the three periods of life result in new aspects of reaction possibilities of the skin under physiological and pathological conditions. The level of replication and production metabolism of skin connective tissue is high during development, maturation and ageing. Proteoglycans or glycosaminoglycans and collagen of skin connective tissue show remarkable turnover rates, during the three life periods, aging included. The interactions between these structure macromolecules and their microheterogeneity are regarded, beside elastin and denaturated collagen and their relationships. Finally the synthesis of proteoglycans and glycosaminoglycans and of collagen as well as the several influences on the several synthesis steps are shown. Therewith we receive new aspects for the therapy of skin diseases.