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[Acquired mid-dermal elastolysis. 2 new cases]

S Maghraoui1, M Grossin, B Crickx

  • 1Service de Dermatologie, CHU X. Bichat, Paris.

Annales De Dermatologie Et De Venereologie
|January 1, 1994
PubMed
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Mid-dermal elastolysis, a rare skin condition, is detailed in two new cases. Both patients presented with characteristic skin changes, highlighting the condition's varied presentation and progression.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Mid-dermal elastolysis is an uncommon connective tissue disorder characterized by the degradation of elastic fibers in the mid-dermis.
  • It typically presents with asymptomatic, non-inflammatory, wrinkled skin, often on the trunk and proximal extremities.

Observation:

  • Two new cases of mid-dermal elastolysis are presented in adult women.
  • The first case involved a 32-year-old woman with perifollicular protrusions and wrinkled limbs, lacking prodromal symptoms.
  • The second case described a 39-year-old woman whose 14-year disease course led to generalized skin involvement, progressing from follicular papules to wrinkled plaques.

Findings:

  • The study documents the clinical presentation and evolution of mid-dermal elastolysis.
  • Case details illustrate the characteristic perifollicular changes and progressive skin wrinkling.

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  • The findings emphasize the potential for widespread cutaneous involvement over time.

    • Implications:

    • These cases contribute to the understanding of mid-dermal elastolysis's clinical spectrum.
    • Further research may elucidate the underlying mechanisms and potential therapeutic targets for this rare condition.
    • Increased awareness of these presentations can aid in earlier diagnosis and management.