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[Acquired mid-dermal elastolysis]

S Maghraoui1, M Grossin, B Crickx

  • 1Service de Dermatologie, CHU Xavier-Bichat, Paris.

Annales De Dermatologie Et De Venereologie
|January 1, 1994
PubMed
Summary
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Acquired mid-dermal elastolysis presents a spectrum of skin conditions, potentially linked by decreasing inflammation. Current treatments for these elastolysis variants remain ineffective, with unknown causes.

Area of Science:

  • Dermatology
  • Pathology

Context:

  • Acquired mid-dermal elastolysis is a rare condition with only sixteen reported cases.
  • Previous classifications by Shelley (1977) identified three variants: post-inflammatory elastolysis with cutis laxa, post-inflammatory elastolysis without cutis laxa, and non-inflammatory elastolysis (mid-dermal elastolysis).

Purpose:

  • To review the literature on acquired mid-dermal elastolysis and its variants.
  • To propose a continuum model for acquired elastolysis based on the degree of initial inflammation.

Summary:

  • A review of reported cases suggests acquired elastolysis may exist on a spectrum, ranging from inflammatory to non-inflammatory forms.
  • Mid-dermal elastolysis represents the non-inflammatory end of this proposed continuum.
  • Common features across all forms include an unknown causative agent, unclear pathogenesis, and ineffectiveness of empirical treatments.

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Impact:

  • This continuum model may aid in classifying challenging cases of acquired elastolysis.
  • Highlights the need for further research into the pathogenesis and effective treatments for these rare elastolytic disorders.