Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fibronectin structure and assembly

J R Potts1, I D Campbell

  • 1Department of Biochemistry, University of Oxford, UK.

Current Opinion in Cell Biology
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

Recent structural studies reveal fibronectin

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosing liver fibrosis: a narrative review of current literature for dermatologists.

The British journal of dermatology·2016
Same author

Risk factors associated with mortality from breast cancer in Waikato, New Zealand: a case-control study.

Public health·2015
Same author

Determinants of long-term outcome in severe alcoholic hepatitis.

Alimentary pharmacology & therapeutics·2013
Same author

De novo Cryoglobulinaemic Mononeuritis Multiplex during Treatment of Chronic Hepatitis C Infection: A Viral Effect or Induced by Pegylated Interferon Alpha?

Case reports in gastroenterology·2012
Same author

Predicting oscillatory dynamics in the movement of territorial animals.

Journal of the Royal Society, Interface·2012
Same author

Brownian walkers within subdiffusing territorial boundaries.

Physical review. E, Statistical, nonlinear, and soft matter physics·2011
Same journal

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
See all related articles

Area of Science:

  • Biochemistry
  • Structural Biology
  • Molecular Biology

Background:

  • Fibronectin is a crucial matrix protein.
  • It is composed of three modular units: Fn1, Fn2, and Fn3.

Purpose of the Study:

  • To elucidate the structure and assembly of fibronectin.
  • To understand fibronectin's structure-function relationships.

Main Methods:

  • Atomic resolution structure determination of fibronectin modules and pairs.
  • Analysis of disulfide-linked monomer joins.
  • Binding and mutation studies.

Main Results:

  • Atomic structures are available for Fn1, Fn2, Fn3 modules, and Fn1-Fn3 pairs.
  • The structure of the disulfide-linked fibronectin monomer join is determined.
  • New data clarify structure-function relationships.

    • Conclusions:

    • Advances in structural determination provide a clearer understanding of fibronectin.
    • This knowledge is key to understanding fibronectin's role in biological processes.