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[The use of methotrexate in cortico-resistant asthma]
I Ortíz Aldana1, L Arreguín Osuna, R Cariño Javier
1Servicio de alergia pediátrica, Instituto Nacional de Pediatría, México, DF.
Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|November 1, 1994
Abstract:
Methotrexate represents a new therapeutic modality in patients with corticoresistant asthma. Its mechanism of action is the competitive inhibition of the folate reducing enzyme, converting folic acid in tetrahydrofolate during the S phase of the cell cycle. It is 50% fixed to albumin and excreted by glomerular filtration and proximal tubule secretion.