[Experimental study of the evaluation of efficacy of fluid replacement based on Parkland formula for burn shock]

In order to investigate the effect of fluid resuscitation of burn shock according to Parkland formula and to find out whether it leaves any damage due to hypoxia, 22 male mongrel dogs with 50% III degrees burn were divided randomly into two groups. Group 1 (14 dogs) received no fluid replacement, whereas in group 2 (8 dogs) Ringer's lactate solution was given according to Parkland formula after the injury. Swan-Ganz catheter was inserted to the pulmonary artery before burn. FAP, CVP, PAP, cardiac output and blood gas analysis were measured preburn and at 2, 6, 12, 18, 24, 36 and 48 hours postburn. The results demonstrated that group 1 dogs all died within 12 hours postburn and group 2 dogs all survived over the shock period. However, even in these survived dogs, markedly decreased cardiac output and oxygen consumption were observed over the first 18 hours postburn. This indicated that fluid replacement according to Parkland formula can not completely correct the inadequacy of tissue perfusion, and it may leave certain damage of oxygen deficiency. Therefore, further improvement in fluid resuscitation and combined treatment for early burn shock to raise cardiac output and improve tissue oxygen delivery may be needed.