[Changes in the contents of plasma SOD and MDA in 50% III degree burn dogs after delayed fluid replacement]

The plasma SOD and MDA content were determined in 50% III degree burn dogs with delayed fluid replacement. The results showed that the activity of plasma total SOD and CuZn-SOD rapidly declined and were obviously lower during the first 5 days postburn than preburn values, while the content of Mn-SOD did not show significant change. The plasma MDA was evidently elevated in 24 hour but returned to the normal level in 48-72 hours after burn, however it distinctly rose again after 72 hours post-burn. The results suggest that delayed fluid replacement induced generation of free radicals after burn injury, with the result of the occurrence of lipid peroxidation.