Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Endocrinological changes in pre- and postmenopause]

T von Holst1

  • 1Abteilung für Gynäkologische Endokrinologie und Fertilitätsstörungen, Universitäts-Frauenklinik Heidelberg.

Therapeutische Umschau. Revue Therapeutique
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Amenorrhea rate after switch from sequential hormone replacement therapy to continuous combined administration of low dose estradiol and norethisterone acetate].

Zentralblatt fur Gynakologie·2002
Same author

Estradiol and levonorgestrel: effects on bleeding pattern when administered in a sequential combined regimen with a new transdermal patch.

Climacteric : the journal of the International Menopause Society·2002
Same author

Postmenopausal hormone replacement therapy and the vascular wall: epidemiology and clinical studies.

VASA. Zeitschrift fur Gefasskrankheiten·2001
Same author

Endometrial safety and tolerability of AERODIOL(R) (intranasal estradiol) for 1 year.

Maturitas·2000
Same author

[Alternatives to hormone replacement therapy: raloxifene and tibolone].

Zeitschrift fur arztliche Fortbildung und Qualitatssicherung·2000
Same author

Clinical equivalence of intranasal and oral 17beta-estradiol for postmenopausal symptoms.

American journal of obstetrics and gynecology·2000
Same journal

[Multimodal Cardiac Imaging: New Developments for Clinical Practice].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Coronary angiography: From cardiac catheterization to advanced interventional cardiovascular imaging].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Athlete's heart: role of cardiac imaging in the prevention of sudden cardiac death].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Multimodal imaging in cardiac amyloidosis and cardiac sarcoidosis].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Inflammatory Heart Disease: The Role of Multimodality Cardiac Imaging in Myocarditis and Pericarditis].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

State-of-the-Art Cardiac Imaging

Therapeutische Umschau. Revue therapeutique·2026
See all related articles

During perimenopause, ovarian function declines, leading to decreased estrogen levels and increased follicle-stimulating hormone (FSH). Postmenopause estrogen production relies on adrenal androgens, with adrenal function remaining stable.

Area of Science:

  • Endocrinology
  • Reproductive biology
  • Hormone metabolism

Context:

  • Perimenopause is characterized by fluctuating ovarian function and steroid hormone metabolism changes.
  • Estrogen levels (estradiol, estrone) decline significantly between ages 49-54.
  • Follicle-stimulating hormone (FSH) levels rise tenfold during this transition.

Purpose:

  • To elucidate the hormonal shifts during perimenopause and postmenopause.
  • To describe the role of adrenal androgens in postmenopausal estrogen production.
  • To highlight the impact of estrogen deficiency on long-term health.

Summary:

  • Ovarian insufficiency in perimenopause causes estrogen decline and FSH rise, leading to menopause around age 51-52.
  • Postmenopausal estrogen is primarily derived from adrenal androgens (androstenedione, testosterone).

Related Experiment Videos

  • Adrenal cortex function persists into old age, unlike ovarian function.

    • Impact:

    • Estrogen deficiency contributes to osteoporosis and coronary heart disease in late postmenopause.
    • Obesity is linked to dysfunctional bleeding during perimenopause due to anovulation.
    • Understanding these hormonal changes is crucial for managing menopausal health issues.