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Triphenyltin as inductor of mitochondrial membrane permeability transition
C Zazueta1, H Reyes-Vivas, C Bravo
1Departamento de Bioquímica, Instituto Nacional de Cardiologia, Ignacio Chavez, México, D. F., México.
Journal of Bioenergetics and Biomembranes
|August 1, 1994
Abstract:
The effect of triphenyltin on mitochondrial Ca2+ content was studied. It was found that this trialkyltin compound induces an increase in membrane permeability that leads to Ca2+ release, drop of the transmembrane potential, and efflux of matrix proteins. Interestingly, cyclosporin A was unable to inhibit triphenyltin-induced Ca2+ release. Based on these results it is proposed that the hyperpermeable state is produced by modification of 2.25 nmol of membrane thiol groups.