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Updated: Aug 9, 2026
10:27
Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation
Published on: June 4, 2015
[Erythrocyte sedimentation rate in clinical practice]
Klinicheskaia Laboratornaia Diagnostika
|September 1, 1994
Summary
The red cell sedimentation rate (ESR) indicates inflammation and disease activity. Understanding its mechanisms, influencing factors, and accurate measurement methods is crucial for clinical diagnosis.
Area of Science:
- Hematology
- Clinical Pathology
- Biomedical Science
Background:
- The erythrocyte sedimentation rate (ESR) is a common hematological test.
- ESR reflects the rate at which red blood cells settle in a standardized tube.
- It is widely used as a non-specific indicator of inflammation.
Purpose of the Study:
- To elucidate the primary mechanisms governing the erythrocyte sedimentation rate (ESR).
- To identify factors that can influence or alter ESR.
- To review established methods for ESR determination and discuss associated errors and clinical significance.
Main Methods:
- Literature review of available data on ESR mechanisms.
- Characterization of factors affecting ESR.
- Description of Panchenkov's micromethod, rapid method, and fractionated test for ESR evaluation.
Main Results:
- Detailed explanation of the biophysical and biochemical principles underlying red blood cell aggregation and sedimentation.
- Identification of key factors such as plasma protein levels (fibrinogen, immunoglobulins), red blood cell morphology, and temperature that influence ESR.
- Comparison of different ESR measurement techniques, highlighting their advantages and limitations.
Conclusions:
- Accurate ESR determination relies on understanding its underlying mechanisms and potential interfering factors.
- Knowledge of common errors is essential for reliable interpretation of ESR results.
- ESR remains a valuable diagnostic parameter for various inflammatory and neoplastic diseases.
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