Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Neuroleptic malignant syndrome. Case reports]

D Berardi1, M Troia, L Veronesi

  • 1Istituto di Psichiatria P. Ottonello, Università degli Studi di Bologna.

Minerva Psichiatrica
|December 1, 1994
PubMed
Summary

Neuroleptic malignant syndrome (NMS) is a severe reaction to neuroleptic drugs. Rapid neuroleptic administration and pre-existing mental status changes are key risk factors, while supportive care is the primary treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The contribution of cannabis use to the increased psychosis risk among minority ethnic groups in Europe.

Psychological medicine·2024
Same author

Emotion dysregulation, impulsivity and anger rumination in borderline personality disorder: the role of amygdala and insula.

European archives of psychiatry and clinical neuroscience·2023
Same author

Evidence of an excessive gender gap in the risk of psychotic disorder among North African immigrants in Europe: a systematic review and meta-analysis.

Social psychiatry and psychiatric epidemiology·2016
Same author

Somatization among ethnic minorities and immigrants: Why does it matter to Consultation Liaison Psychiatry?

Journal of psychosomatic research·2015
Same author

Disparities in mental health care provision to immigrants with severe mental illness in Italy.

Epidemiology and psychiatric sciences·2014
Same author

A systematic review of metabolic side effects related to the use of antipsychotic drugs in dementia.

International psychogeriatrics·2013

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Neuroleptic malignant syndrome (NMS) is a rare but serious adverse reaction to neuroleptic medications.
  • It is characterized by mental status changes, muscular rigidity, hyperthermia, and autonomic instability.
  • Despite increased attention, etiopathogenesis and treatment require further investigation.

Observation:

  • This study prospectively observed 9 cases of NMS in psychiatric patients.
  • Seven cases met Levenson's diagnostic criteria, while two presented with milder symptoms.
  • Pre-syndrome mental status changes (e.g., stupor, coma, psychomotor excitement) were noted in 7/9 cases.

Findings:

  • NMS risk appears independent of neuroleptic class, D2 receptor affinity, or total dosage.

Related Experiment Videos

  • A rapid neuroleptic loading rate is identified as a significant risk factor.
  • Pre-existing severe mental status changes may also increase NMS risk and prompt dosage increases.

    • Implications:

    • Prompt discontinuation of neuroleptics and supportive therapy are crucial for NMS management.
    • Bromocriptine and dantrolene may be considered second-line treatments.
    • Careful reintroduction of low-dose, low-potency neuroleptics after recovery appears safe.