[Hyperinsulinemia in women with hyperandrogenemia]

In the peripheral blood serum from 24 females with hyperandrogenemia and 12 controls we determined concentrations of total testosterone (T), dehydroepiandrosterone-sulfate (DHEA-S), sex hormone binding globulin (SHBG) and insulin, and calculated Free Androgen Index. In hyperandrogenemic patients we found significantly higher mean concentrations of total testosterone when compared to the controls (n = 192; 3.5 + 1.9 vs n = 76; 1.9 = 0.9; P < 0.001), insulin (n = 95; 23.2 = 15.1; vs n = 33; 9.9 = 4.8; p < 0.001) DHEA-S (n = 70; 6.2 = 1.6 vs n = 27; 3.6 = 1.9; p < 0.001), FAI (n = 65; 27 = 32.9 vs n = 33; 3.9 = 2.1; p < 0.001) while the levels of SHBG in hyperandrogenemics were significantly lower than in the controls (n = 67; 24.6 = 15.9 vs n = 33; 52.8 = 19.3; p < 0.001). We found a positive correlation between the relative body mass and insulin concentrations (r = 0.67) in the form of the repeated sampling mean values; between the relative body mass and the mean values of the total testosterone concentrations (r = 0.42) and between the total testosterone concentrations and insulin (r = 0.32).