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Vitamin E does not prevent exercise-induced increase in pulmonary clearance
1Institut National de la Santé et de la Recherche Médicale Unité 296, Département de Physiologie, Créteil, France.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|November 1, 1994
Summary
Sustained exercise increases lung epithelial permeability. Vitamin E supplementation did not alter this effect, suggesting lipid peroxidation is not the primary cause of exercise-induced lung permeability changes.
Area of Science:
- Exercise Physiology
- Pulmonary Medicine
- Cellular Biology
Background:
- Sustained exercise is known to increase alveolar epithelial permeability.
- The exact mechanism behind this exercise-induced permeability increase remains unclear.
- Lipid peroxidation has been hypothesized as a potential contributing factor.
Purpose of the Study:
- To investigate the role of lipid peroxidation in exercise-induced increases in alveolar epithelial permeability.
- To determine if vitamin E supplementation can mitigate exercise-induced changes in lung permeability.
Main Methods:
- A single-blind crossover study involving seven healthy volunteers.
- Pulmonary clearance of aerosolized 99mTc-labeled diethylenetriaminepentaacetate (99mTc-DTPA) was measured.
- Exercise consisted of 60 minutes on a treadmill at 80% maximal oxygen uptake.
- Measurements were taken before and after a 3-week supplementation with oral vitamin E (1,000 IU/day).
Main Results:
- Vitamin E supplementation did not significantly reduce the exercise-induced increase in pulmonary 99mTc-DTPA clearance.
- The findings suggest that lipid peroxidation is not the primary mechanism responsible for the observed increase in lung permeability.
Conclusions:
- The exercise-induced increase in lung epithelial permeability is unlikely to be primarily caused by lipid peroxidation.
- Results support the hypothesis that mechanical effects of hyperventilation on intercellular tight junctions may be the main driver of increased lung permeability during exercise.