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Fungal infections after renal transplantation
Abstract:
Fungal infections occurred in 3 of 22 renal transplants (13.6%). Two patients developed rhinocerebral phycomycosis, and Rhizopus arrhizus was isolated from cultures of the nasal conchae. Both patients were treated with systemic amphotericin B. Three-and-a-half months after transplantation the third patient developed an acute ureteral obstruction secondary to infection with Aspergillus nidulans; this necessitated removal of the graft. There was no immediate mortality associated with these fungal infections but there was immediate loss of the grafts in the two patients.
Insights
Fungal infections like phycomycosis and aspergillosis affect renal transplant recipients. These infections can lead to graft loss, highlighting the need for vigilance in transplant patients.
Area of Science:
- Nephrology
- Infectious Diseases
- Transplantation Immunology
Background:
- Renal transplantation is a life-saving procedure for end-stage renal disease.
- Immunosuppression is crucial for graft survival but increases infection risk.
- Fungal infections pose a significant threat in immunocompromised patients.
Observation:
- Three of 22 renal transplant recipients (13.6%) developed fungal infections.
- Two cases involved rhinocerebral phycomycosis caused by Rhizopus arrhizus.
- One case presented as ureteral obstruction due to Aspergillus nidulans.
Findings:
- Systemic amphotericin B was used for treatment.
- Two patients experienced immediate graft loss due to fungal infections.
- No immediate mortality was directly attributed to these fungal infections.
Implications:
- Fungal infections are a serious complication in renal transplant recipients.
- Prompt diagnosis and treatment are essential to prevent graft loss.
- Further research into prophylactic strategies may be warranted.