Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers01:22

Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers

Class I antiarrhythmic drugs are used to treat various types of arrhythmias or irregular heart rhythms. These drugs block the sodium (Na+) channels in the cardiac cells, thereby affecting the movement of electrical impulses across the heart. Class I antiarrhythmic drugs are divided into three subgroups: Class IA, Class IB, and Class IC, each with distinct mechanisms of action and effects on the heart.
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
ECG Interpretation of Arrhythmias I: Sinus Arrhythmias01:16

ECG Interpretation of Arrhythmias I: Sinus Arrhythmias

Arrhythmias are disturbances in the heart's rhythm that lead to abnormal heartbeats. These irregularities can originate from different parts of the heart and are classified based on their origin and nature.
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism, and...
Dysrhythmias V: Evaluating Dysrhythmias01:30

Dysrhythmias V: Evaluating Dysrhythmias

Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of omega-3 polyunsaturated fatty acid-enriched diets in the prevention of ventricular fibrillation.

Asia Pacific journal of clinical nutrition·2014
Same author

Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets.

Prostaglandins, leukotrienes, and essential fatty acids·2000
Same author

Omega-3 polyunsaturated fatty acids and ventricular fibrillation: the possible involvement of eicosanoids.

Prostaglandins, leukotrienes, and essential fatty acids·1999
Same author

Dietary lipid modification of myocardial eicosanoids following ischemia and reperfusion in the rat.

Lipids·1995
Same author

Dietary lipids and adipose tissue fatty acids in the marmoset monkey (Callithrix jacchus).

Comparative biochemistry and physiology. Comparative physiology·1994
Same author

Dietary fats and cardiac arrhythmia in primates.

Nutrition (Burbank, Los Angeles County, Calif.)·1994

Related Experiment Video

Updated: Jul 24, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Lipids and cardiac arrhythmia

J S Charnock1

  • 1Cardiac Research Unit, Glenthorne Laboratory, CSIRO, Australia.

Progress in Lipid Research
|January 1, 1994
PubMed
Summary

Dietary fatty acids significantly impact heart rhythm. Saturated fats increase vulnerability to lethal cardiac arrhythmia, while polyunsaturated fats offer protection. Monounsaturated fats like oleic acid may also promote arrhythmia.

Area of Science:

  • Cardiovascular Science
  • Nutritional Biochemistry

Background:

  • Heart disease involves atherosclerosis, thrombogenesis, and cardiac arrhythmia.
  • Cardiac arrhythmia is a major cause of sudden cardiac death and out-of-hospital mortality.
  • The role of dietary lipids in heart disease pathogenesis is complex and often generalized.

Purpose of the Study:

  • To review the role of dietary fatty acids in cardiac arrhythmia.
  • To differentiate the effects of various fatty acids on myocardial vulnerability.
  • To examine the impact of monounsaturated fatty acids on cardiac rhythm during ischemic events.

Main Methods:

  • Review of animal studies investigating dietary fatty acid effects on the heart.
  • Analysis of myocardial vulnerability to ventricular fibrillation under stress.

More Related Videos

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology
10:41

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Published on: September 13, 2022

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction
03:42

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

Published on: March 29, 2024

Related Experiment Videos

Last Updated: Jul 24, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology
10:41

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Published on: September 13, 2022

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction
03:42

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

Published on: March 29, 2024

  • Examination of oleic acid's effect in a rat model of coronary artery ligation.

    • Main Results:

    • Diets high in saturated fatty acids increase myocardial vulnerability to lethal arrhythmia.
    • Diets rich in polyunsaturated fatty acids (PUFA) decrease the probability of lethal cardiac rhythm disorders.
    • Oleic acid (a monounsaturated fatty acid) promoted arrhythmia in a rat model, similar to saturated fatty acids.

    Conclusions:

    • Dietary fatty acids play a critical role in determining susceptibility to cardiac arrhythmia.
    • Polyunsaturated fatty acids appear protective against lethal arrhythmias, while saturated fats increase risk.
    • Monounsaturated fatty acids, specifically oleic acid, may not be neutral and can promote arrhythmia under ischemic conditions.