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Isoelectric restriction of human immunoglobulin isotypes
1Laboratoire d'Immunologie, Faculté de Médecine de Nancy, Vandoeuvre Les Nancy, France.
Biochimica Et Biophysica Acta
|February 23, 1995
Abstract:
The partition of human serum immunoglobulins along a pH gradient of ampholynes was investigated using the recently developed method of preparative isoelectrofocusing. Each isotype was demonstrated to display a specific pI range, with limited overlapping. IgA appear to be the most acidic serum immunoglobulins while IgG are clearly basic.