Physiology of hemostasis

Area of Science:

• Biochemistry
• Physiology
• Medical Science

Background:

• Acute insults to the hemostatic system pose diagnostic and therapeutic challenges.
• Effective management requires identifying involved hemostatic compartments and understanding complex enzyme/inhibitor interactions.

Purpose of the Study:

• To provide a logical review of the basic mechanisms of hemostasis.
• To focus on key elements of the biochemistry and physiology of hemostasis.

Main Methods:

• Focused review of current concepts in hemostasis.
• Emphasis on vessel wall, platelet, and plasma factor physiology and biochemistry.
• Detailed examination of plasma proteins, biocybernetic principles, and interrelationships of enzyme systems.

Main Results:

• Key elements of hemostasis biochemistry and physiology are presented.
• Biocybernetic principles and interrelationships of enzyme systems (coagulation, fibrinolysis, kinin, complement) are highlighted.

Conclusions:

• A working knowledge of basic hemostasis mechanisms aids in diagnosis and therapy.
• Understanding fundamental principles provides a foundation for developing novel diagnostic and therapeutic modalities.