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Hemodynamic and physiologic changes during support with an implantable left ventricular assist device
P M McCarthy1, R M Savage, C D Fraser
1Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, OH 44195.
The Journal of Thoracic and Cardiovascular Surgery
|March 1, 1995
Summary
The HeartMate 1000 IP left ventricular assist device significantly improved heart function in patients awaiting transplantation, with no thromboembolic events and a high survival rate post-transplant.
Area of Science:
- Cardiology
- Medical Devices
- Transplantation
Background:
- Patients awaiting heart transplantation often require mechanical circulatory support.
- The HeartMate 1000 IP is a left ventricular assist device designed for this purpose.
Purpose of the Study:
- To assess the hemodynamic effectiveness and physiological changes in patients supported by the HeartMate 1000 IP device.
- To evaluate the safety and outcomes of this device as a bridge to heart transplantation.
Main Methods:
- A study of 25 patients (mean age 50) undergoing bridge to heart transplantation.
- Hemodynamic parameters and physiological markers were monitored before and after device implantation.
- Patient survival, duration of support, and adverse events were recorded.
Main Results:
- Significant improvements were observed in cardiac index, left atrial pressure, pulmonary artery pressure, and right ventricular function.
- Nineteen out of 25 patients (76%) were successfully transplanted and discharged with 100% survival post-transplant.
- No thromboembolic events occurred over 1500 patient-days of support with antiplatelet therapy alone.
Conclusions:
- The HeartMate 1000 IP device effectively improves hemodynamic and physiological function in patients with advanced heart failure.
- Long-term support with this device demonstrates a low risk of thromboembolism.
- The HeartMate device offers a viable alternative to medical therapy for patients awaiting heart transplantation.