Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central hypotensive effect of propranolol

C T Dollery, P J Lewis

    Postgraduate Medical Journal
    |January 1, 1976
    PubMed
    Summary

    Propranolol lowers blood pressure by acting on the central nervous system (CNS). This antihypertensive effect is linked to beta-adrenoceptor blockade, not its dextro isomer.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Concise Guide to PHARMACOLOGY 2013/14: overview.

    British journal of pharmacology·2014
    Same author

    Intracellular drug concentrations.

    Clinical pharmacology and therapeutics·2013
    Same author

    Acute effects of varying doses of propranolol upon oxygen haemoglobin affinity in man.

    British journal of clinical pharmacology·2012
    Same author

    Metabolism of terbutaline in man and dog.

    British journal of clinical pharmacology·2012
    Same author

    Lapatinib-induced liver injury characterized by class II HLA and Gilbert's syndrome genotypes.

    Clinical pharmacology and therapeutics·2012
    Same author

    Chairman's Introduction.

    Proceedings of the Royal Society of Medicine·2010

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Cardiovascular Research

    Background:

    • The precise mechanism by which propranolol lowers arterial pressure is not fully understood.
    • Existing animal studies suggest a role for the central nervous system (CNS) in propranolol's hypotensive effects.

    Purpose of the Study:

    • To investigate the central nervous system (CNS) contribution to propranolol's antihypertensive action.
    • To determine if the hypotensive effect is related to beta-adrenoceptor blockade.

    Main Methods:

    • Intravenous infusion of propranolol in conscious rabbits.
    • Monitoring of arterial pressure.
    • Measurement of preganglionic sympathetic nervous activity.

    Main Results:

    • Propranolol infusion lowered arterial pressure in conscious rabbits.
    • A concurrent decrease in preganglionic sympathetic nervous activity was observed.
    • The dextro isomer of propranolol did not produce these effects.

    Conclusions:

    • Propranolol exerts a hypotensive effect through a central action on the nervous system.
    • This central action involves a decrease in sympathetic nervous outflow.
    • The hypotensive effect is specifically mediated by beta-adrenoceptor blockade.

    Related Experiment Videos