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Confirmation of sulfonamide residues in kidney tissue by liquid chromatography-mass spectrometry
1Analytical Chemistry Unit, Central Veterinary Laboratory, Addlestone, Surrey, UK.
The Analyst
|December 1, 1994
Abstract:
The development of a method to confirm the presence of sulfonamide residues in kidney tissues at levels at or above the maximum residue limit (MRL, 100 ng g-1 total sulfonamide) using a tandem mass spectrometer [i.e., mass spectrometry-mass spectrometry (MS-MS)] interfaced to a high-performance liquid chromatography is described. Although sulfonamides can be determined using a single quadrupole mass spectrometer with pseudo-MS-MS, advantages in interfacing to a tandem mass spectrometer are demonstrated.