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Cloning of a swelling-induced chloride current related protein from rabbit heart
1Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
Biochimica Et Biophysica Acta
|March 8, 1995
Abstract:
Recently, pIcln has been reported to be a regulator of a swelling-induced chloride conductance. We have cloned a cDNA RCL-H1 from rabbit heart, of which primary structure is highly homologous to that of pIcln. Outwardly rectifying currents were recorded in oocytes expressing RCL-H1, which is consistent with the result of pIcln. RNA blot analysis revealed the widespread expression of RCL-H1 mRNA in rabbit tissues. RCL-H1 may play an important role in regulating cell volume and give a clue to revealing molecular structure of swelling-induced chloride channel(s).