Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central and peripheral catecholamine mechanisms in circulatory control

J L Reid, C T Dollery

    Cardiology
    |January 1, 1976
    PubMed
    Summary

    Central and peripheral catecholamine neurones regulate blood pressure. Levodopa impacts blood pressure centrally and peripherally in Parkinson's patients, affecting baroreflex sensitivity and potentially causing hypotension.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Concise Guide to PHARMACOLOGY 2013/14: overview.

    British journal of pharmacology·2014
    Same author

    Intracellular drug concentrations.

    Clinical pharmacology and therapeutics·2013
    Same author

    Acute effects of varying doses of propranolol upon oxygen haemoglobin affinity in man.

    British journal of clinical pharmacology·2012
    Same author

    Metabolism of terbutaline in man and dog.

    British journal of clinical pharmacology·2012
    Same author

    Lapatinib-induced liver injury characterized by class II HLA and Gilbert's syndrome genotypes.

    Clinical pharmacology and therapeutics·2012
    Same author

    Chairman's Introduction.

    Proceedings of the Royal Society of Medicine·2010

    Area of Science:

    • Neuroscience
    • Cardiovascular Physiology

    Background:

    • Catecholamine-containing neurons regulate cardiovascular function via central and peripheral adrenergic mechanisms.
    • Impaired sympathetic activity can lead to baroreflex dysfunction and postural hypotension.

    Purpose of the Study:

    • To investigate the central and peripheral effects of levodopa on blood pressure regulation in parkinsonian patients.
    • To understand levodopa's impact on baroreflex sensitivity and hypotension.

    Main Methods:

    • Observational study in parkinsonian patients.
    • Assessment of cardiovascular parameters and baroreflex sensitivity.
    • Analysis of levodopa's effects on blood pressure.

    Main Results:

    • Levodopa demonstrated both central and peripheral effects on blood pressure.
    • Changes in central function can alter baroreflex sensitivity.
    • Supine hypotension with preserved postural compensation is a common finding.

    Conclusions:

    • Levodopa influences cardiovascular regulation through both central and peripheral pathways.
    • Understanding these mechanisms is crucial for managing blood pressure in Parkinson's disease.
    • Further research is needed to elucidate the precise interactions of levodopa in the central nervous system.

    Related Experiment Videos