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Malignant hidroacanthoma simplex. A case report and literature review
E Piqué1, M Olivares, M L Espinel
1Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
Dermatology (Basel, Switzerland)
|January 1, 1995
Summary
Malignant hidroacanthoma simplex, a rare skin cancer, was identified on a patient's lower limb. Immunohistochemical analysis revealed specific tumor markers, aiding in diagnosis and understanding this uncommon neoplasm.
Area of Science:
- Dermatopathology
- Oncology
- Immunohistochemistry
Background:
- Hidroacanthoma simplex is a rare benign adnexal tumor.
- Malignant transformation is exceptionally uncommon, with limited literature.
- This case presents a rare instance of malignant hidroacanthoma simplex.
Observation:
- A 73-year-old female presented with a lesion on her right lower limb.
- The lesion was histopathologically diagnosed as malignant hidroacanthoma simplex.
- Immunohistochemical staining was performed on the neoplastic tissue.
Findings:
- Carcin o-embryonic antigen (CEA) was detected.
- Epithelial membrane antigen (EMA) was detected.
- Both CEA and EMA were localized to the luminal border of ductal structures within neoplastic cell aggregations.
Implications:
- The immunohistochemical profile supports the diagnosis of malignant hidroacanthoma simplex.
- CEA and EMA expression may serve as diagnostic markers for this rare malignancy.
- Further research into the pathogenesis and behavior of malignant hidroacanthoma simplex is warranted.