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Four cases of Wolfram syndrome: ophthalmologic findings and complications
H Seynaeve1, A Vermeiren, A Leys
1Department of Ophthalmology, St. Rafaël hospital, University of Leuven, Belgium.
Bulletin De La Societe Belge D'Ophtalmologie
|January 1, 1994
Abstract:
The association of diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) is known as Wolfram syndrome. The ophthalmic signs are progressive decrease in visual acuity, constriction of the peripheral visual field with or without central scotoma, colour vision disturbances and bilateral optic disc atrophy. Diabetic retinopathy is a rare complication. We describe the ophthalmological complications in four patients with this syndrome.