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Microphthalmia and associated abnormalities in inbred black mice
R S Smith1, T H Roderick, J P Sundberg
1Jackson Laboratory, Bar Harbor, ME 04609-1500.
Laboratory Animal Science
|December 1, 1994
Summary
Microphthalmia and anophthalmia occur frequently in C57BL mice due to genetic factors, impacting research. These eye abnormalities, including corneal opacities and cataracts, are linked to developmental issues and can mimic human conditions.
Area of Science:
- Ophthalmology
- Developmental Biology
- Genetics
Background:
- Microphthalmia and anophthalmia are common in C57BL mice, affecting up to 12% of individuals.
- These conditions are often misattributed to husbandry issues but stem from genetic predispositions.
- Ocular infections in affected mice result from faulty tear drainage due to malformations.
Purpose of the Study:
- To highlight the frequent occurrence of microphthalmia and anophthalmia in C57BL mice.
- To differentiate genetic ocular malformations from husbandry failures.
- To emphasize the need for careful examination of ocular structures in C57BL strains.
Main Methods:
- Histologic examination of ocular tissues from C57BL mice.
- Comparative analysis of ocular abnormalities in mice and humans.
- Review of existing literature on C57BL mouse eye development and malformations.
Main Results:
- Consistent and variable ocular findings, including corneal opacities, adhesions, iris/ciliary body abnormalities, cataracts, and retinal folding.
- A predilection for right-eye abnormalities and subtle microphthalmia mimicking anophthalmia.
- Increased incidence of abnormalities with alcohol exposure during embryogenesis.
Conclusions:
- Ocular malformations in C57BL mice are genetically determined and require careful microscopic evaluation.
- These findings share similarities with human anterior segment dysgenesis and fetal alcohol syndrome.
- Proper understanding of these genetic conditions is crucial for accurate interpretation of research involving C57BL mice.