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Functional Transcranial Doppler Ultrasound for Monitoring Cerebral Blood Flow
09:41

Functional Transcranial Doppler Ultrasound for Monitoring Cerebral Blood Flow

Published on: March 15, 2021

Cerebral hemodynamics in hypertensive patients compared with normotensive volunteers. A transcranial Doppler study

H Sugimori1, S Ibayashi, K Irie

  • 1Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Stroke
|July 1, 1994
PubMed

Insights

Early hypertension shows higher cerebral blood flow velocity, while chronic hypertension exhibits increased cerebrovascular resistance and altered pulsatility. These findings suggest distinct cerebral vascular changes at different hypertension stages.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Medical Imaging

Background:

  • Hypertension significantly impacts cerebral hemodynamics.
  • Understanding vascular changes in early versus chronic hypertension is crucial for patient management.

Purpose of the Study:

  • To investigate cerebral hemodynamic differences between early and chronic hypertension stages.
  • To utilize transcranial Doppler sonography for assessing cerebral blood flow velocity and resistance.

Main Methods:

  • Employed transcranial Doppler sonography to measure cerebral hemodynamics in 10 early hypertensive, 16 chronic hypertensive, and 16 normotensive subjects.
  • Calculated mean blood flow velocity, Gosling pulsatility index (PI), Fourier PI of the first harmonic (Fourier PI1), and cerebrovascular resistance.
  • Used 3D mapping to identify the M1 segment of the middle cerebral arteries.

Main Results:

  • Early hypertensive subjects had higher mean blood flow velocity (71.7 cm/s) compared to chronic hypertensive (56.9 cm/s) and normotensive (63.2 cm/s) groups.
  • Chronic hypertensive subjects showed significantly higher Fourier PI1 (0.32) and cerebrovascular resistance (2.08 mm Hg/cm per second) than both normotensive and early hypertensive groups.
  • Gosling PI mirrored the mean blood flow velocity trends across all groups.

Conclusions:

  • Early hypertension is characterized by increased cerebral blood flow velocity with near-normal vascular resistance and pulsatility.
  • Chronic hypertension demonstrates near-normal velocity but elevated Fourier PI1 and cerebrovascular resistance, indicating arteriopathy and arteriolopathy.
  • The study highlights distinct hemodynamic profiles differentiating early and advanced stages of hypertension.
Abstract

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