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Forces exerted by locomoting cells

T Oliver1, J Lee, K Jacobson

  • 1Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill 27599-7090.

Seminars in Cell Biology
|June 1, 1994
PubMed
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Cellular locomotion involves complex forces during protrusion, retraction, and adhesion. This review explores recent measurements and mechanisms of forces generated by moving cells on surfaces.

Area of Science:

  • Cell Biology
  • Biophysics

Background:

  • Cellular movement along surfaces is a complex process.
  • It involves dynamic cell extension, retraction, and adhesion to the substratum.
  • Understanding the forces involved is crucial for cell biology.

Purpose of the Study:

  • To review the forces exerted by locomotory cells.
  • To discuss recent force measurements in cell movement.
  • To explore possible mechanisms generating these forces.

Main Methods:

  • This review synthesizes findings from recent force measurements.
  • It discusses assays developed for measuring cell-exerted forces.
  • Mechanisms of force generation are explored based on current literature.

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Main Results:

  • Locomotory cells generate forces during protrusion and retraction.
  • Cell-substratum adhesion is critical for force generation.
  • New assays are being developed to quantify these forces.

Conclusions:

  • Cellular locomotion relies on the generation and application of forces.
  • Further research into force measurement and mechanisms is ongoing.
  • Understanding these forces is key to comprehending cell migration.