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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Related Experiment Video

Updated: Jul 15, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Prevention of allergic disorders

W R Solomon1

  • 1Division of Allergy, University of Michigan Medical Center, Ann Arbor.

Pediatrics in Review
|August 1, 1994
PubMed
Summary

Preventing pediatric allergic disease involves avoiding postnatal allergens, particularly in the first year of life. Strategies targeting specific allergens, like dust mites, offer effective primary and secondary prevention for children.

Area of Science:

  • Pediatric Allergy and Immunology
  • Environmental Health
  • Genetics and Disease Prevention

Background:

  • Allergic diseases cause significant pediatric morbidity and dysfunction.
  • Disease expression is influenced by IgE production, target organ sensitivity, and allergen exposure.
  • Genetic factors play a role in IgE production and organ-specific responses.

Purpose of the Study:

  • To clarify the mechanisms of pediatric allergic disease.
  • To identify effective preventive strategies for allergic conditions in children.
  • To evaluate the impact of allergen exposure on disease development.

Main Methods:

  • Review of current evidence on allergic disease determinants.
  • Analysis of genetic and environmental factors influencing allergic disease.

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Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

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Last Updated: Jul 15, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

  • Evaluation of preventive strategies, including dietary modifications and allergen avoidance.

    • Main Results:

    • Gestational allergen avoidance is not supported for newborn allergy prevention.
    • Postnatal allergen avoidance, especially in the first 6-12 months, reduces allergic risk.
    • Excluding food allergens may decrease atopic dermatitis but not respiratory symptoms.
    • Limiting exposure to inhalant allergens (dust mites, danders) is effective for primary and secondary prevention.

    Conclusions:

    • Allergen-specific avoidance is key to preventing pediatric allergic diseases.
    • Early postnatal allergen avoidance strategies are crucial for high-risk infants.
    • Environmental modifications, such as reducing indoor allergens, offer practical prevention methods.