Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Side effects with amiodarone therapy

R Shukla1, N I Jowett, D R Thompson

  • 1Department of Medicine, Leicester General Hospital, UK.

Postgraduate Medical Journal
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perfect health not so perfect after all - a methodological study on patient-reported outcome measures in 2574 patients following percutaneous coronary intervention.

Health and quality of life outcomes·2025
Same author

Intrinsic Dimensionality as a Metric for the Impact of Mission Design Parameters.

Journal of geophysical research. Biogeosciences·2022
Same author

Poultry processing and the application of microbiome mapping.

Poultry science·2020
Same author

Comparison of the Automated with the Semi-Automatic Coulter Counter Method and the Direct Microscopic Somatic Cell Count (DMSCC) on Raw Milk Samples <sup>1</sup>.

Journal of food protection·2019
Same author

Inactivation of Salmonellae in Autoclaved Ground Beef Exposed to Constantly Rising Temperatures <sup>1</sup>.

Journal of food protection·2019
Same author

Collaborative Study of the Coulter Counter-Chemical Method for Counting Somatic Cells in Raw Milk <sup>1</sup>.

Journal of food protection·2019
Same journal

Two cases of toxic epidermal necrolysis with severe ocular involvement treated with adjunctive tofacitinib.

Postgraduate medical journal·2026
Same journal

Diastolic dysfunction and diabetes: the DIADAD study-a retrospective cohort study from Liverpool.

Postgraduate medical journal·2026
Same journal

Care, cash, and proof: forensic accountability for war-related starvation.

Postgraduate medical journal·2026
Same journal

Response to traumatic injuries in polo players in England.

Postgraduate medical journal·2026
Same journal

Aids to venesection and parenteral drug administration in patients with difficult veins.

Postgraduate medical journal·2026
Same journal

Diagnostic reasoning in clinical neurology: a comprehensive primer.

Postgraduate medical journal·2026
See all related articles

Monitoring amiodarone levels does not predict side effects, though longer treatment and higher doses increase risks. Clinical monitoring remains crucial for managing adverse events associated with this anti-arrhythmic drug.

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Medicine

Background:

  • Amiodarone hydrochloride is a widely used anti-arrhythmic medication for ventricular and supraventricular arrhythmias.
  • Its efficacy is often limited by a high incidence of adverse effects.

Purpose of the Study:

  • To assess the predictive value of serum amiodarone and its metabolite levels for drug-induced side effects.
  • To correlate treatment duration and cumulative dosage with side effect prevalence.

Main Methods:

  • Analysis of 109 patients from a Leicester General Hospital amiodarone treatment register.
  • Examination of the prevalence of known amiodarone side effects in relation to serum drug levels, treatment duration, and cumulative dosage.

Main Results:

Related Experiment Videos

  • Cutaneous side effects and subclinical thyroid dysfunction correlated with increased treatment duration and cumulative amiodarone dosage.
  • Neither serum amiodarone nor its metabolite levels predicted the occurrence of side effects.

Conclusions:

  • Clinical monitoring for side effects is essential for patients on amiodarone.
  • Measuring serum amiodarone levels may help avoid excessively high doses, mitigating cumulative dose-related adverse events, despite not predicting specific side effects.