Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alpha-adrenoceptors

R R Ruffolo1, J P Hieble

  • 1Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406.

Pharmacology & Therapeutics
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Recent research has identified seven alpha-adrenoceptor subtypes, revealing their molecular structure and function. Understanding these G-protein coupled receptors is key to their physiological and therapeutic relevance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synapse selection based on differences in synapse turnover.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·2014
Same author

Apoptosis and congestive heart failure.

Trends in cardiovascular medicine·2011
Same author

Drugs targeting adrenergic receptors: does interaction with a specific subtype confer therapeutic advantage?

Current opinion in drug discovery & development·2009
Same author

Pharmacology of the angiotensin II receptor antagonist, eprosartan.

Expert opinion on investigational drugs·2005
Same author

Rabbit alpha2-adrenoceptors: both platelets and adipocytes have alpha2A-pharmacology.

The Journal of pharmacology and experimental therapeutics·2001
Same author

Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same journal

Nipocalimab and other FcRn blockers in neuromuscular disorders.

Pharmacology & therapeutics·2026
Same journal

C26:0-lysophosphatidylcholine in X-linked adrenoleukodystrophy.

Pharmacology & therapeutics·2026
Same journal

The CircRNA/miRNA axis in breast cancer: From molecular mechanisms to clinical translation.

Pharmacology & therapeutics·2026
Same journal

Glymphatic-meningeal lymphatic dysfunction in epilepsy: novel mechanistic insights and therapeutic avenues.

Pharmacology & therapeutics·2026
Same journal

The neurovascular unit under siege: Molecular mechanisms and potential drug target for cerebral edema.

Pharmacology & therapeutics·2026
Same journal

A-type potassium channels in pain signaling: Fundamental mechanisms and pathophysiological roles.

Pharmacology & therapeutics·2026
See all related articles

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Biochemistry

Background:

  • Alpha-adrenoceptors are crucial for physiological regulation.
  • Understanding their molecular structure and function is advancing rapidly.
  • New subtypes have been identified using biochemical and pharmacological methods.

Purpose of the Study:

  • To review major advances in alpha-adrenoceptor research.
  • To discuss the molecular structure, function, and classification of alpha-adrenoceptor subtypes.
  • To explore the physiological and pathophysiological roles of alpha-adrenoceptors.

Main Methods:

  • Biochemical techniques
  • Pharmacological techniques
  • Receptor cloning and expression

Related Experiment Videos

  • G-protein coupling studies

    • Main Results:

    • At least seven alpha-adrenoceptor subtypes have been identified.
    • Molecular structures and biochemical functions of subtypes are being elucidated.
    • Alpha-adrenoceptors are G-protein coupled receptors involved in intracellular signaling.
    • Research is ongoing into receptor-G-protein interactions and their roles in disease.

    Conclusions:

    • Significant progress has been made in understanding alpha-adrenoceptors.
    • Further research is needed to fully elucidate receptor-G-protein interactions.
    • Alpha-adrenoceptors have critical roles in homeostasis and disease states.
    • These advances have therapeutic relevance.