Related Experiment Videos
Interaction of the protein kinase Raf-1 with 14-3-3 proteins
H Fu1, K Xia, D C Pallas
1Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115.
Science (New York, N.Y.)
|October 7, 1994
Abstract:
Members of a family of highly conserved proteins, termed 14-3-3 proteins, were found by several experimental approaches to associate with Raf-1, a central component of a key signal transduction pathway. Optimal complex formation required the amino-terminal regulatory domain of Raf-1. The association of 14-3-3 proteins and Raf-1 was not substantially affected by the activation state of Raf.