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Updated: Aug 5, 2026
05:53
Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
[Cytomegaloviruses--clinical aspects and therapy]
1Abteilung für Medizinische Virologie und Epidemiologie der Viruserkrankungen, Hygieneinstitut der Universität Tübingen.
Therapeutische Umschau. Revue Therapeutique
|August 1, 1994
Summary
Human cytomegalovirus (HCMV) poses risks to vulnerable populations. Rapid diagnostics are needed to detect drug resistance in immunosuppressed patients treated with antivirals like Ganciclovir and Foscarnet.
Area of Science:
- Virology
- Immunology
- Clinical Medicine
Context:
- Human cytomegalovirus (HCMV) is a significant opportunistic pathogen.
- It affects fetuses, transplant recipients, and individuals with HIV or other immunosuppressive conditions.
- HCMV infection can lead to severe disease in these vulnerable groups.
Purpose:
- To describe clinical features of congenital HCMV infection.
- To outline HCMV infection and disease in immunosuppressed transplant recipients.
- To discuss clinical diagnostic methods for HCMV monitoring.
Summary:
- Ganciclovir and Foscarnet are key antivirals for treating HCMV manifestations like retinitis, pneumonitis, and hepatitis.
- Drug resistance to Ganciclovir and Foscarnet by HCMV strains is a growing concern in immunosuppressed patients.
- There is an urgent need for rapid diagnostic tools to detect HCMV drug resistance.
Impact:
- Informs clinical management of HCMV infections.
- Highlights the critical need for advanced diagnostic solutions.
- Aims to improve treatment outcomes for HCMV patients facing drug resistance.
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