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The T genes in embryogenesis

B G Herrmann1, A Kispert

  • 1Max-Planck Institut für Entwicklungsbiologie, Abteilung Biochemie, Tübingen, Germany.

Trends in Genetics : TIG
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

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The mouse T (Brachyury) gene is crucial for mesoderm formation and notochord development. Its role in embryonic pattern formation is conserved across species, making it a key research tool.

Area of Science:

  • Developmental biology
  • Genetics
  • Molecular biology

Background:

  • The mouse T (Brachyury) locus, identified in 1927, plays a significant role in embryonic development.
  • It is known to be involved in mesoderm formation and notochord differentiation.

Purpose of the Study:

  • To investigate the function of the T (Brachyury) gene in embryonic development.
  • To understand its role in mesoderm and notochord formation.

Main Methods:

  • Cloning of homologous T genes from various species.
  • Expression analysis of the T gene in developing embryos.

Main Results:

  • The T gene encodes a putative transcription factor.
  • This factor is specifically expressed in nascent mesoderm and differentiating notochord.

Related Experiment Videos

  • Homologous genes have been identified in Xenopus laevis, zebrafish, and Halocynthia roretzi.

    • Conclusions:

    • The T (Brachyury) gene is essential for mesoderm and notochord development.
    • It serves as a vital tool for studying embryonic pattern formation.
    • Conservation of T genes across species highlights its fundamental role in development.