Dorsoventral patterning in Drosophila oogenesis

Dorsoventral polarity in the egg chamber of Drosophila involves the localization of maternal gurken RNA to the dorsal side of the oocyte. The gurken protein has homology to secreted growth factors and may bind to the torpedo/DER receptor tyrosine kinase present on the adjacent follicle cells. This localized signal from the oocyte to the follicle cells appears to initiate a cascade of events leading to dorsal follicle cell differentiation, and delimiting and orienting the future dorsoventral axis of the embryo.