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Updated: Aug 10, 2026
14:23
A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
[HIV seropositivity and desire for children]
R Henrion1, L Mandelbrot, G Firtion
1Clinique Universitaire Port-Royal, Paris.
Contraception, Fertilite, Sexualite (1992)
|March 1, 1993
Summary
HIV-positive individuals desiring children require careful reproductive counseling. Gynecologists must assess risks and explore options like donor insemination to minimize HIV transmission.
Area of Science:
- Reproductive Health
- Infectious Diseases
- Gynecology
Context:
- Increasing numbers of HIV-infected individuals desire to have children.
- Gynecologists face complex ethical and medical dilemmas in counseling these couples.
- Pregnancy in HIV-infected women carries a risk of vertical transmission to the fetus/infant.
Purpose:
- To provide guidance for reproductive counseling of HIV-infected individuals and couples.
- To outline considerations for HIV-discordant couples (one partner HIV-positive, the other negative).
- To detail strategies for minimizing heterosexual HIV transmission during conception attempts.
Summary:
- Reproductive counseling for HIV-infected individuals involves assessing maternal health, partner status, and social support.
- For HIV-discordant couples, evaluating the infected partner's immune status is crucial as transmission risk increases with immune suppression.
- Techniques to eliminate HIV from sperm are not established; donor insemination or timed intercourse during ovulation are alternatives.
Impact:
- Informed decision-making for HIV-infected individuals and couples regarding family planning.
- Reduction in mother-to-child and heterosexual transmission of HIV.
- Improved management of reproductive health in the context of HIV infection.
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