[Quantitative study of oncogene p21ras expression in premalignant lesion and carcinoma of the stomach]

The oncogene P21ras expression in premalignant lesions and carcinomas of the stomach was quantitatively studied by flow cytometry and immunofluorescence methods and the relation of P21ras to DNA ploidy and cellular proliferation was analysed. The results showed that P21ras expression was higher in carcinomas than premalignant lesions of the stomach. The fluorescence index in P21ras expression increased with the rise in histological grade. DNA ploidy correlated with the amount of P21ras expression.