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Ketoprofen suppositories in rheumatological practice

L Simon, F Blotman

    Rheumatology and Rehabilitation
    |January 1, 1976
    PubMed
    Summary
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    Ketoprofen suppositories showed local side effects in some patients, leading to treatment discontinuation. However, the suppository form may offer prolonged action, potentially enhancing outcomes for inflammatory rheumatism when used alongside ketoprofen capsules.

    Area of Science:

    • Pharmacology
    • Gastroenterology
    • Rheumatology

    Background:

    • Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for inflammatory conditions.
    • Alternative drug delivery systems, such as rectal suppositories, are explored to optimize therapeutic effects and patient compliance.

    Purpose of the Study:

    • To evaluate the preliminary efficacy and tolerability of ketoprofen suppositories in patients with inflammatory rheumatism.
    • To assess local and systemic side effects associated with ketoprofen suppository administration.

    Main Methods:

    • A cohort of 30 patients received ketoprofen suppositories at a dosage of 200 mg twice daily.
    • Adverse events, including local rectal irritation and systemic complaints, were systematically recorded.
    • Treatment discontinuation rates due to side effects were analyzed.

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    Main Results:

    • Seven patients discontinued treatment on the first day due to local side effects (rectal burning, difficulty retaining the suppository).
    • An additional five patients abandoned treatment later due to local (burning) or systemic (gastric pain) side effects.
    • Preliminary findings suggest potential for prolonged action with the suppository formulation.

    Conclusions:

    • Ketoprofen suppositories were associated with a notable incidence of local and systemic side effects, leading to treatment cessation in a significant proportion of patients.
    • The suppository presentation may offer prolonged ketoprofen release, potentially beneficial for managing inflammatory rheumatism, especially when administered nocturnally in conjunction with oral formulations.