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Related Experiment Videos

Methotrexate in childhood psoriasis

B Kumar1, S Dhar, S Handa

  • 1Department of Dermatology, Venereology, and Leprology, PGIMER, Chandigarh, India.

Pediatric Dermatology
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

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Methotrexate effectively treated childhood psoriasis, including severe forms like psoriatic erythroderma and pustular psoriasis. Most children achieved disease control with manageable side effects like nausea and vomiting.

Area of Science:

  • Pediatric Dermatology
  • Rheumatology
  • Pharmacology

Background:

  • Childhood psoriasis presents significant challenges, with limited treatment options for severe or recalcitrant cases.
  • Methotrexate (MTX) is a potential therapeutic agent for pediatric psoriasis, but its efficacy and safety require further investigation.

Purpose of the Study:

  • To evaluate the efficacy and safety of methotrexate in treating childhood psoriasis.
  • To determine optimal dosage, treatment duration, and disease-free intervals in pediatric patients.

Main Methods:

  • A retrospective study of seven children (ages 3.5-16 years) with various forms of psoriasis treated with weekly oral methotrexate.
  • Disease severity, treatment response, duration, cumulative dose, and side effects were monitored.

Related Experiment Videos

  • Liver biopsies were performed pre-treatment in four patients.

    • Main Results:

    • Methotrexate controlled various psoriasis types, including psoriatic erythroderma and generalized pustular psoriasis, within 6-10 weeks.
    • The mean treatment duration was 38.8 weeks, with a mean cumulative dose of 683.6 mg.
    • Mild side effects, primarily nausea and vomiting, were reported in three patients. Pre-treatment liver biopsies showed grade I changes.

    Conclusions:

    • Methotrexate is an effective treatment for childhood psoriasis, demonstrating good disease control with a favorable safety profile.
    • The study supports the use of methotrexate as a viable therapeutic option for pediatric psoriasis, including severe presentations.